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Mathematical Systems Biology of Cancer II |
| October 24, 2007 to October 26, 2007 |
| Organized By: Joe Gray, Elizabeth Purdom, Terry Speed and Paul Spellman. |
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| Return to Workshop Description |
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Segmentation of Array CGH Data with Application to Allele Specific Copy Number, Clonality, and Copy Number Variation
Friday October 26, 2007
04:15PM - 05:00PM
Speakers:
Adam Olshen
Abstract:
Cancer progression often involves alterations in DNA sequence copy number. Multiple microarray platforms now facilitate high-resolution copy number assessment of entire genomes in single experiments. This technology is generally referred to as array comparative genomic hybridization (array CGH). I will discuss our technique for identifying regions of abnormal copy number in array CGH data, which is called circular binary segmentation (CBS). The first published version of CBS was criticized for being slow. I will present our methods for greatly speeding up the procedure. I will also show our approaches to recent copy number applications including allele-specific copy number, clonality, and copy number variation.
This is joint work with E.S. Venkatraman.
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