Pathway Logic Models"
Mathematical Systems Biology of Cancer
May 03,2006 11:15 AM to 12:15 PM
Speakers:
Talcott, Carolyn
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Abstract: |
Pathway Logic is an approach to modeling cellular processes based on symbolic
logic. It allows one to model aspects of the structure and state of interacting components, to
represent individual process steps (reactions) and to study possible ways a system could evolve
using techniques based on logical inference. Reactions can be modeled at many levels of detail
ranging from micro steps representing events such as phosphorlyation at specific sites or binding
of protein domains to macro steps such as the results of signaling or metabolic modules. Given a
network of reactions and a specification of cellular components one can use logical inference to
query the network about possible reaction pathways and outcomes. In this talk we will explain how
signal transduction reactions are represented in Pathway Logic, and illustrate some of the
questions that one can ask a model using the Pathway Logic Assistant. Then we will describe
several ways in which a Pathway Logic model can be used to analyze gene expression data. |
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Lecture #12314
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