Integrative Radiation Biology
Mathematical Systems Biology of Cancer
May 03,2006 01:45 PM to 02:30 PM
Speakers:
Barcellos-Hoff, Mary-Helen
|
 |
Abstract: |
In the context of multicellular organisms, an orchestrated response to DNA damage by
ionizing radiation is important for rapid restoration of homeostasis and long-term prevention of
cancer. The challenge in predicting radiation health effects in humans is to understand how
cellular responses occurring in a multicellular context are integrated to produce an organismal
response. Experimental studies show that radiation exposure elicits responses that can produce
effects in non-irradiated bystander cells or can lead to a high frequency of genomic instability in the
progeny of irradiated cells. This has motivated a substantial effort to both describe and quantify
these non-targeted responses. One may argue that, more importantly, those data have heightened
awareness that many types of cell interactions contribute to long term radiation effects, and that
multicellular responses are poorly integrated into the current paradigms of radiation effects and
their consequences in terms of human health. A model of radiation response based on the systems
biology principles of network interconnectivity and spatial organization is discussed that would
reconcile the apparent contradiction of these cellular responses within the higher order structure of
tissues and organisms. |
|
|
Lecture #12318
Need help? Visit our help pages at http://www.msri.org/communications/vmath/hints
|
|
|
|
| See more of our Streaming Videos on our main VMath - Streaming Video page. |
