Random matrix theory (RMT) was introduced into the theoretical physics community by Eugene Wignerinthe 1950s as a model for the scattering resonances of neutrons off large nuclei. In multivariate statistics, random matrix models were introduced in the late 1920s by John Wishart and subsequently developed by Anderson, James and others. Since these early beginnings RMT has found an extraordinary variety of mathematical, physical and engineering applications that, to name some, include number theory, stochastic growth models, tiling problems and wireless communications. In the spring of 1999, MSRI hosted a very successful and influential one-semester program on RMT and its applications. At the workshops during the semester, there was a sense of excitement as brand new and very recent results were reported. The goal of the 2010 Program is to showcase the many remarkable developments that have taken place since 1999 and to spur further developments in RMT and related areas of interacting particle systems (IPS) and integrable systems (IS) as well as to highlight various applications of RMT. Invited Speakers Mark Adler (Brandeis University), Ioana Dumitriu (Massachusetts Institute of Technology, MIT), Alan Edelman (Massachusetts Institute of Technology, MIT), Partik Ferrari (University of Bonn), Nikolai Makarov (California Institute of Technology), Neil O'Connell (University of Warwick), Andrei Okounkov (Princeton University), Jeremy Quastel (University of Toronto), Nikolai Reshetikhin (University of California, Berkeley), Tomohiro Sasamoto (Tokyo Institute of Technology), Timo Seppäläinen (University of Wisconsin), Herbert Spohn (Technical University of Munich), Kazumasa Takeuchi (University of Tokyo), Benedek Valko (University of Wisconsin), Balint Virag (University of Toronto), Harold Widom (University of California, Santa Cruz), Paul Wiegmann (University of Chicago), Lauren Williams (University of California, Berkeley) Bibliography (PDF) Accommodations: A block of rooms has been reserved at the Rose Garden Inn. Reservations may be made by calling 1-800-992-9005 OR directly on their website. Click on Corporate at the bottom of the screen and when prompted enter code MATH (this code is not case sensitive). By using this code a new calendar will appear and will show MSRI rate on all room types available. The cut-off date for reservations is November 19, 2010. A block of rooms has been reserved at the Hotel Durant. Please mention the workshop name and reference the following code when making reservations via phone, fax or e-mail: MSRIRANDOMMATRIX. If you are making your reservations on line, please go to Hotel Durant website, choose your dates of stay and enter the "123MSRI" promo code in the box. New, completely renovated Hotel Shattuck Plaza has rooms available for you! MSRI’s preferred rate is $131. Guests can either call the hotel’s main line, 510-845-7300, and ask for the MSRI rate or go to http://www.hotelshattuckplaza.com, click on "Corporate Rates" in the reservation screen and type the code msri10.